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Current studies show that treatment of cortical neurons with glutamate resulted in an increase in Bax with a decrease in Bcl-2 proteins, loss of the MMP followed by a release of cytochrome c, and activation of caspase-9, representing the classical mitochondrial apoptotic pathway ( Figure 3 )

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Ergothioneine is a natural amino acid derived from plants and can accumulate in animals, which can effectively remove OH groups and prevent the formation of OH from H 2 O 2