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RF (Ed.) UpToDate, Wolters Kluwer, 2026

LDN is an immune-modulator that decreases the number of TH1 cells and TH17 cells results in immunebalance with the regulation of cytokines release [36]

Cross-cancer comparisons reveal that although the SSP serves conserved functions in sustaining one-carbon unit supply and mediating therapeutic resistance across cancer types, the remarkable heterogeneity of its upstream regulatory mechanismsincluding Kras/FGFR3 mutations, MYC-mediated stemness maintenance, and m6A epigenetic modificationsdictates that therapeutic strategies must be precisely tailored