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However, securing a reliable supply often introduces logistical hurdles

*Correspondence: Zuyun Zhang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

aurantium have been linked to serious clinical adverse events, mostly related to CV issues, including syncope, QT interval prolongation, MI, ischemic stroke, angina, tachycardia, bradycardia, hypotension, vasospasm, ventricular fibrillation, and ischemic colitis (239, 242)

South Africa does not produce high-purity trans-resveratrol due to the absence of facilities capable of extracting it from Japanese knotweed or grape sources at pharmaceutical-grade levels