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(Phytomedicines act on Correa cascade), we identify plants or compounds based on their advantages at different stages, which will facilitate researchers in selecting a specific plant or compound corresponding with their study purpose

Acknowledgements This work is financially supported by the Research Grant Committee of Hong Kong (Project Code: 17119621, 17111424, 12100025), the Health and Medical Research Fund (Project Code: 21222151, 19201591 and 15162961), and the Innovation and Technology Fund (Project Code: PRP/028/22FX & PRP/029/24FX)

The secondary antibody was Goat Anti-Rabbit IgG H&L Antibody (HRP) at 1:10,000 dilution

In addition to the systemic differences between rodents and humans, several mechanistic constraints further reduce the likelihood that GLP-1secreting engineered probiotics will succeed clinically