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Regarding unaffected relatives of LHON patients, currently, treatment with idebenone is not recommended, but lifestyle counselling, especially about quitting smoke and alcohol, is highly suggested [75]

Focus on Homocysteine Levels: Measuring homocysteine levels is often a more reliable indicator of potential health risks than MTHFR gene mutation testing alone

Oncogene 26:11011109 Meyer AJ, Brach T, Marty L, Kreye S, Rouhier N, Jacquot JP, Hell R (2007) Redox-sensitive GFP in Arabidopsis thaliana is a quantitative biosensor for the redox potential of the cellular glutathione redox buffer