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While hydrogen may exert its effects through hormonal pathways such as free radical scavenging, inflammation inhibition, and regulating ghrelin, its regulatory impact on -syn nucleoprotein aggregation warrants in-depth investigation in conjunction with proteomic analyses (Matsumoto et al., 2013)

However, we also identified two cell models in which treatment with Fer or Trolox does not rescue cells from death and dependence on cysteine is maintained, given that the use of NAC or ME effectively prevents cell death (Supplementary Fig 1b, c), similar to observations in other studies [21]