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10.1016/s0960-0760(03)00220-6 J

One possible explanation is your body adjusting to B12 replenishment

178 Compared with traditional single-target agents, SIRT1 activators simultaneously modulate several critical pathways, including metabolism, immune responses, and oxidative balance, offering a network reprogramming therapeutic advantage, particularly in the early stages of the disease when multiple processes are synergistically dysregulated